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BRAIN GANGLIOSIDE PATTERNS OF VERTEBRATES
Author(s) -
Avrova N. F.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb11996.x
Subject(s) - ganglioside , vertebrate , biology , central nervous system , carp , zoology , fish <actinopterygii> , amphibian , lamprey , sialic acid , biochemistry , endocrinology , ecology , fishery , gene
— The ganglioside content in brains of representatives of six vertebrate classes (lamprey, ray, sheat‐fish, carp, frog, triton, tortoise, hen, pigeon, rabbit, rat and monkey) was determined. In most cases a correlation was found between the level of nervous organization and the ganglioside content of brain. In fish and amphibian brain ganglioside concentration is half to one third that in mammalian brain. Ganglioside composition of higher vertebrate brains (mammals, birds and reptiles) has many similar features. Four main gangliosides with 1‐3 NANA residues in their molecules–G 1 *, G 2 , G 3 and G 4 –constitute 80‐90 per cent of total ganglioside NANA. Fractions G 2a † G o and G 5 are present in much lesser amounts. Species peculiarities in distribution of NANA among different fractions were noted. The brain gangliosides of lower vertebrates–fish and amphibia–are unusual in having a high proportion of polysialogangliosides, containing 4 and 5 NANA residues, and a lower content of monosialogangliosides. In ray brain a considerable part of gangliosides has a reduced carbohydrate chain.