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SOME NEUROCHEMICAL ASPECTS OF FLUOROCITRATE INTOXICATION 1
Author(s) -
Patel A.,
Koenig H.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb11992.x
Subject(s) - neurochemical , glycogen , glutamine , convulsant , glutamate receptor , chemistry , endocrinology , medicine , spinal cord , metabolism , in vivo , biochemistry , amino acid , biology , neuroscience , receptor , microbiology and biotechnology
— Some metabolic and biochemical effects of fluorocitrate were studied in vivo in rat brain and cat spinal cord. During the preconvulsant and convulsant phases of fluorocitrate poisoning the contents of free glutamate, glutamine and aspartate declined progressively, while that of alanine increased. Incorporation of 14 C from [U‐ 14 C]glucose into these amino acids also decreased, although somewhat more gradually. GABA exhibited a biphasic change, its content rising after an initial decrease while its relative specific activity rose initially and subsequently diminished. Incorporation of 14 C from [U‐ 14 C]glucose and [U‐ 14 C]lysine into neural protein declined sharply. The citric acid content rose markedly in rat brain and cat spinal cord. In rat brain the glycogen content declined but ATP and ammonia contents were unchanged. The significance of these results with respect to energy metabolism and the possible mechanism of the convulsions during fluorocitrate poisoning is discussed.