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MEDIATION BY β‐ADRENERGIC RECEPTORS OF EFFECT OF NOREPINEPHRINE ON PINEAL SYNTHESIS OF [ 14 C]SEROTONIN AND [ 14 C]MELATONIN
Author(s) -
Wurtman R. J.,
Shein H. M.,
Larin F.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb03741.x
Subject(s) - phenoxybenzamine , medicine , endocrinology , melatonin , adenosine , propranolol , norepinephrine , pineal gland , serotonin , chemistry , receptor , biology , dopamine
Rat pineal organs maintained in organ culture converted [ 14 C]tryptophan to [ 14 C]serotonin and [ 14 C]melatonin. The synthesis of both indoles was stimulated by the presence of norepinephrine or dibutyryl adenosine 3′,5′‐monophosphate. This effect of norepinephrine could be blocked by the α ‐adrenergic blocking drug, propranolol, but was not modified by the a‐adrenergic blocking agent, phenoxybenzamine. Neither blocking agent modified the pineal response to dibutyryl adenosine 3′,5′‐monophosphate. Unlike dibutyryl adenosine 3′,5′‐monophosphate, the naturally occurring adenosine phosphates did not stimulate synthesis of [ 14 C]melatonin in vitro.