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MONOAMINE OXIDASE: AN APPROXIMATION OF TURNOVER RATES
Author(s) -
Goridis C.,
Neff N. H.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb03740.x
Subject(s) - pargyline , monoamine oxidase , monoamine neurotransmitter , medicine , cycloheximide , endocrinology , chemistry , superior cervical ganglion , monoamine oxidase inhibitor , cervical ganglia , enzyme , biology , serotonin , biochemistry , protein biosynthesis , receptor
One hour after the intravenous injection of pargyline (10 mg/kg), the activity of monoamine oxidase (EC 1.4.3.4) in various brain regions, in the submaxillary gland and in the superior cervical ganglion of the rat was inhibited by about 95 per cent. From the return of monoamine oxidase activity with time, we estimated that the half‐life of the enzyme is about 11 days in the brain and 4 days in the submaxillary gland and superior cervical ganglion. The return of activity was inhibited by treatment with cycloheximide. The half‐life of monoamine oxidase in brain regions bore no relationship to the turnover rates of the monoamines.