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FATTY ACID COMPOSITION OF CEREBROSIDES, SULPHATIDES AND CERAMIDES IN MURINE SUDANOPHILIC LEUCODYSTROPHY: THE JIMPY MUTANT
Author(s) -
Joseph K. C.,
Hogan E. L.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb03737.x
Subject(s) - mutant , sphingolipid , myelin , fatty acid , biochemistry , chemistry , biology , gene , central nervous system , endocrinology
The fatty acid composition of cerebrosides, sulphatides and ceramides was determined at 15‐16 days post partum in the brain of the Jimpy mutant and in littermate controls. There was a marked deficit in the long chain fatty acids (C 22 ‐C 24 ) of cerebrosides and sulphatides of Jimpy brain, with the unsubstituted fatty acids affected more than the alpha‐hydroxy fatty acids. A decrease of long chain normal fatty acids was also found in the ceramides of Jimpy brain. The deficit of long chain fatty acids in these sphingolipids of the Jimpy brain was more severe than that found in the Quaking mutant which has a less extensive disorder of myelin formation.