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EFFECTS OF POTASSIUM AND GLUTAMATE ON BRAIN CORTEX SLICES: UPTAKE AND RELEASE OF GLUTAMIC AND OTHER AMINO ACIDS
Author(s) -
Arnfred T,
Hertz L
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb00564.x
Subject(s) - glutamate receptor , efflux , glutamine , potassium , glutamic acid , amino acid , chemistry , biochemistry , leucine , biophysics , biology , organic chemistry , receptor
— Effects of an increased concentration of K + (55 m m ) in the medium on fluxes of glutamate and other amino acids in the presence and absence of 10 m m ‐glutamate were studied. The following observations were made: (1) The efflux of glutamate is slightly increased by excess K + . The glutamate efflux is smaller than the potassium fluxes. (2) The K + ‐induced increase of glutamate efflux is enhanced under anoxia or in glutamate‐containing media. (3) The influx of glutamate is unaffected or slightly increased by excess K + . (4) The efflux of GABA is increased by excess K + , both in the absence and in the presence of glutamate. (5) Efflux of glutamine, leucine and lysine is increased by excess K + , but only provided that glutamate is also present in the medium. (6) Efflux of glutamate and of GABA is increased by addition of 10 m m ‐glutamate.