Premium
CHANGES IN GLUTAMIC ACID AND GLUTAMINE METABOLISM IN THE RAT BRAIN AFTER WHOLE BODY X‐IRRADIATION
Author(s) -
Hǎulicǎ A.,
Trandafirescu M.,
Ababei L.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb00201.x
Subject(s) - glutamine , glutaminase , ammonia , glutamine synthetase , metabolism , glutamate dehydrogenase , irradiation , incubation , glutamate receptor , glutamic acid , endogeny , biochemistry , chemistry , medicine , biology , endocrinology , amino acid , receptor , nuclear physics , physics
— After whole body irradiation with X‐rays, an increase in the free ammonia concentration in the rat brain was observed. Parallel to this increase, evidence was found of a strong activation of glutaminase. Incubation increased the endogenous ammonia‐forming capacity of brain homogenates to a much greater extent in irradiated rats than in normal rats. Glutamine synthetase activity decreased within the first 2 h after irradiation but remained unchanged at 24 and 96 h after irradiation. On the other hand, at 48 h after irradiation, glutamate dehydrogenase activity in the brain had fallen by 75 per cent in comparison with the initial activity. It is concluded that metabolic systems other than the glutamine‐glutamic acid system contribute to the ammonia formation in the brain after irradiation.