Premium
THE EFFECT OF BICUCULLINE, METRAZOL, PICROTOXIN AND STRYCHNINE ON THE RELEASE OF [ 3 H]GABA FROM RAT BRAIN SLICES
Author(s) -
Johnston G. A. R.,
Mitchell J. F.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb00200.x
Subject(s) - strychnine , picrotoxin , bicuculline , convulsants , chemistry , gaba receptor antagonist , pharmacology , convulsant , neuroscience , endocrinology , gabaa receptor , anesthesia , medicine , anticonvulsant , biochemistry , epilepsy , biology , receptor
— Each of the four convulsants used significantly influenced the release of [ 3 H]‐GABA from brain slices, without affecting [ 3 H]GABA uptake. Bicuculline (10 −5 M, but not 10‐fold higher or lower concentrations) potentiated the electrically evoked release of [ 3 H]GABA but not the resting release, whereas metrazol (10 −4 to 10 −6 M) was found to inhibit resting but not electrically evoked release. Strychnine (10 −4 and 10 −5 M) and picro‐toxin (10 −4 M) inhibited electrically evoked release.