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MEMBRANE FRAGMENTS FROM MYELIN TREATED WITH DIFFERENT DETERGENTS
Author(s) -
McIlwain D. L.,
Graf L.,
Rapport M. M.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb00182.x
Subject(s) - myelin , cationic polymerization , membrane , myelin sheath , chemistry , protein subunit , ionic bonding , chromatography , biochemistry , biophysics , central nervous system , biology , organic chemistry , neuroscience , ion , gene
— Bovine CNS myelin treated with cationic, anionic and non‐ionic detergents yielded fragments which did not sediment in water at 56,500 g for 15 min. Substantial chemical and immunological differences were observed among the myelin fragments produced by these detergents. The chemical and immunological characteristics of such membrane products were also dependent upon the concentration of detergent. These and similar findings with other biological membranes emphasize the difficulties in using detergents to obtain and examine proposed subunit structures.