Premium
THE INTERACTION BETWEEN PERIPHERAL NERVE POLYANIONS AND ALCIAN BLUE
Author(s) -
Langley O. K.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb03723.x
Subject(s) - peripheral nerve , macromolecule , chemistry , staining , biophysics , nerve conduction , peripheral nervous system , myelin sheath , node of ranvier , anatomy , neuroscience , pathology , biochemistry , biology , central nervous system , myelin , medicine
—A study of the staining characteristics of Alcian blue in mammalian peripheral myelinated nerve in the presence of added electrolyte has enabled a comparison to be made of polyanions, formerly shown to be present at nodes of Ranvier, with other chemically defined macromolecules present in the same tissue. Two types of polyanion were shown to exist at nodes, one probably carboxylated and the other containing in addition sulphate ester groups. The possible physiological functions of such materials are discussed in relation to the role played by the nodes of Ranvier in conduction of the nerve impulse.