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PATTERN OF RNA SYNTHESIS IN RABBIT CORTEX DURING SLEEP
Author(s) -
VitaleNeugebauer A.,
Giuditta A.,
Vitale B.,
Giaquinto S.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb03375.x
Subject(s) - rna , wakefulness , cerebral cortex , electroencephalography , sleep (system call) , cortex (anatomy) , brain cortex , homogeneous , neuroscience , biology , biophysics , chemistry , microbiology and biotechnology , biochemistry , endocrinology , gene , physics , thermodynamics , computer science , operating system
— The pattern of RNA biosynthesis in rabbit cerebral cortex was examined during periods of physiological sleep and wakefulness monitored with EEG techniques. The types of newly synthesized RNA were analysed by sedimentation on sucrose gradients. In experiments lasting 60 and 105 minutes the labelling ratio of RNA sedimenting in two regions of the gradient (28 S ‐50 S 50 S ) increased with decreasing percentages of EEG synchronization. Analysis of the radioactivity distributions of five homogeneous experiments in terms of moments confirmed the dependence of the RNA synthetic pattern on the electric state of the cortex. The possible nature of the RNA species involved in this effect is discussed.