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HYDRAZIDE‐INDUCED SEIZURES AND CEREBRAL OF LEVELS γ‐AMINOBUTYRIC ACID: A RE‐EVALUATION
Author(s) -
Abrahams Dawne E.,
Wood J. D.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb03368.x
Subject(s) - hydrazide , convulsant , chemistry , aminobutyric acid , pharmacology , anesthesia , medicine , endocrinology , biochemistry , organic chemistry , receptor
— Data have been presented indicating that in chicks the time lag in the onset of seizures after the administration of hydrazides was not caused by a slow penetration of the convulsant agents into the brain. A correlation was evident between the rate of decrease in concentration of cerebral GABA and the susceptibility of chicks to hydrazide‐induced seizures. Earlier studies precluding a role for GABA in hydrazide‐induced convulsions were re‐examined.