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CALCIUM CONTENT AND EXCHANGE IN NEOCORTICAL TISSUES DURING THE CATION MOVEMENTS INDUCED BY GLUTAMATES
Author(s) -
Ramsey R. L.,
McIlwain H.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb03349.x
Subject(s) - potassium , calcium , chemistry , sodium , glutamate receptor , bicarbonate , biophysics , efflux , tetrodotoxin , sodium glutamate , sodium bicarbonate , biochemistry , medicine , endocrinology , biology , receptor , organic chemistry , raw material
—1 Guinea pig neocortical tissues incubated in glucose‐bicarbonate media reached stable calcium contents of 2 μat./g of which 0‐35 μat.Ca/g was in a space accessible to inulin. 2 Addition of l ‐glutamate salts caused a prompt increase in intracellular calcium at rates up to 7 μat./g tissue/hr. 3 Using 45 Ca, this increase was found to be due to an accelerated influx of Ca and a diminished efflux. The rate of influx could be doubled by 1 m m‐l ‐glutamate. 4 Tetrodotoxin at concentrations of 66‐330 nM diminished 45 Ca entry, both in the absence and presence of added glutamate. 5 Tissue sodium and potassium contents are also reported under some conditions, and the extent to which calcium may condition sodium and potassium movements is discussed.