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INTERRELATIONSHIPS BETWEEN PYRIDOXAL PHOSPHATE AND PYRIDOXAL KINASE IN RABBIT BRAIN 1
Author(s) -
Ebadi M. S.,
McCoy E. E.,
Kugel R. B.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb02247.x
Subject(s) - pyridoxal , pyridoxal phosphate , pyridoxine , pyridoxal 5 phosphate , biochemistry , chemistry , kinase , enzyme , cofactor
—An inverse relationship was demonstrable between the concentration of pyridoxal phosphate and the activity of pyridoxal kinase in rabbit brain. The administration of pyridoxine elevated the concentration of pyridoxal phosphate and decreased the activity of pyridoxal kinase. Conversely, the administration of deoxypyridoxine decreased the concentration of pyridoxal phosphate and increased the activity of pyridoxal kinase. The increase in the activity of pyridoxal kinase by deoxypyridoxine was blocked by actinomycin D or puromycin. These results were interpreted to indicate that the tissue availability of pyridoxal phosphate regulated the activity of pyridoxal kinase.