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GLYCOPROTEIN METABOLISM IN DEVELOPING MOUSE BRAIN 1
Author(s) -
Dutton G. R.,
Barondes S. H.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb02244.x
Subject(s) - glycoprotein , fucose , glucosamine , polyacrylamide gel electrophoresis , electrophoresis , molecular mass , biochemistry , gel electrophoresis , metabolism , biology , chemistry , microbiology and biotechnology , enzyme
—Incorporation of [ 14 C]fucose or [ 14 C]glucosamine into the glycoproteins of developing mouse brain was studied using polyacrylamide gel electrophoresis. Between 1 and 10 days after birth two fractions of soluble glycoproteins were extensively labelled, but by 15 days after birth incorporation into these fractions was no longer prominent. These glycoproteins have apparent molecular weights in the range of 150,000‐250,000, as estimated by the electrophoretic procedure. The more rapidly migrating fraction has a half‐life of about 1 week whereas the other is far more stable.