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Effects of dichloroisopropylarterenol on respiration, nucleotide ∼ P and phospholipids of slices of cerebral cortex
Author(s) -
Morazain R.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb02230.x
Subject(s) - cerebral cortex , phosphatidic acid , epinephrine , nucleotide , respiration , chemistry , medicine , endocrinology , norepinephrine , cortex (anatomy) , phospholipid , biochemistry , biology , neuroscience , anatomy , membrane , gene , dopamine
In a Recent report Hokin (1969) showed that norepinephrine stimulated the incorporation of 32 P into phosphatidic acid (PA) of slices of cerebral and cerebellar cortex and into phosphaditylinositol (PI) of slices of cerebral cortex. In the course of our experiments on agents affecting the metabolism of phospholipids, the effects of epinephrine and its antagonist, dichloroisopropylarterenol (DCI), on the labelling of energy‐rich nucleotides and phospholipids of cerebral tissue have been measured. Epinephrine had no significant effect but DCI stimulated the incorporation of 32 P into PA by 165 per cent and into PI by 90 per cent.