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MERCAPTOPROPIONIC ACID: A CONVULSANT THAT INHIBITS GLUTAMATE DECARBOXYLASE 1
Author(s) -
Lamar C.
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb02197.x
Subject(s) - glutamate decarboxylase , aminooxyacetic acid , convulsant , pyridoxal phosphate , biochemistry , glutamine , chemistry , transaminase , glutamate receptor , glutamine synthetase , pyridoxal , enzyme , cofactor , amino acid , receptor
—3‐Mercaptopropionic (MP) and 4‐mercaptobutyric (MB) acids caused convulsions in rats after the intraperitoneal administration of 32 and 200 mg/kg body wt. respectively. These compounds competitively inhibited glutamate decarboxylase (L‐glutamate 1‐carboxy‐lyase; EC 4.1.1.15) of rat brain and bacterial GABA transaminase (4‐aminobutyrate: 2‐oxoglutarate aminotransferase; EC 2.6.1.c). Glutamine synthetase (L‐glutamate: ammonia ligase (ADP); EC 6.3.1.2) was not affected. Pyridoxal phosphate added in vitro did not reverse the inhibition. Action of these compounds is compared to methionine sulphoximine, a bacterial exotoxin (lactylaminopimelic acid) and to hydrazinopropionic acid.