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THE EFFECT OF DENERVATION ON INCORPORATION OF 32 P AND [ 3 H]GLYCEROL BY THE MUSCLE MEMBRANE
Author(s) -
Bunch W,
Kallsen G,
Berry J,
Edwards C
Publication year - 1970
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1970.tb00541.x
Subject(s) - tenotomy , denervation , sphingomyelin , membrane , medicine , endocrinology , phospholipid , phosphatidylserine , chemistry , phosphatidylcholine , in vivo , biochemistry , biology , anatomy , tendon , microbiology and biotechnology
— The incorporation in vivo of 32 P 1 was significantly increased in all glycerophosphatide of preparations of denervated muscle membrane in frogs. There was no increase in incorporation of 32 P 1 into sphingomyelin. Disuse induced by tenotomy did not significantly increase incorporation of 32 P 1 into phospholipids of the muscle membrane. The phospholipid content of muscle membranes remained unchanged as a result of denervation or tenotomy. Denervation produced an increase in the incorporation of [2‐ 3 H]glycerol into all glycerophosphatides in parallel with the increase in 32 P 1 incorporation. Although the stimulated incorporation of 32 P 1 was increased in the regions of the muscle membrane rich in endplates, the most marked effect was in the endplate‐poor region where activity in phosphatidylserine was most markedly increased.