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COMPARISON OF CEREBRAL REGIONAL METABOLISM OF [ 14 C]LEUCINE FOLLOWING THIRD VENTRICLE AND INTRAVENOUS ADMINISTRATION IN THE CAT
Author(s) -
Berl S.,
Frigyesi T. L.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb10381.x
Subject(s) - caudate nucleus , cerebellum , pons , neocortex , glutamine , leucine , glutamate receptor , chemistry , medulla oblongata , biology , cerebral ventricle , endocrinology , medicine , central nervous system , anatomy , biochemistry , neuroscience , amino acid , receptor
— In the cat, intraventricularly injected [ 14 c]leucine does not appear to penetrate into the cerebral tissue, whereas intravenously injected [ 14 c]leucine readily penetrates the blood‐brain barrier. The latter route of administration of [ 14 c]leucine produces rather uniform distribution of radioactivity in cortical and subcortical regions as well as diencephalic, lower brain stem, and cerebellar regions. Data consistent with compartmentation of the glutamate‐glutamine system were observed in all regions except the cerebellum and head of the caudate nucleus. In the latter two areas, the ratios of the specific activity of glutamine to glutamic acid was less than 1, whereas in all other areas it was greater than 1. The turnover rate of the brain protein was fastest in the cerebellum and neocortex and slowest in the caudate nucleus and in the pons and medulla.