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ELECTROLYTE DISTRIBUTION IN RABBIT SUPERIOR CERVICAL GANGLION 1
Author(s) -
Woodward J. K.,
Bianchi C. P.,
Erulkar S. D.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb10367.x
Subject(s) - sodium , potassium , electrolyte , chemistry , superior cervical ganglion , extracellular , ganglion , saline , endocrinology , anatomy , analytical chemistry (journal) , chromatography , biochemistry , biology , electrode , organic chemistry
— Superior cervical ganglia of the rabbit were removed and analysed for Na + , K + , Ca 2+ , Mg 2+ and Cl − . The mean electrolyte content in μmole/g wet wt. was as follows: Na + , 64.7 ± 1.3; K + , 65.1 ± 2.7; Ca 2+ , 3.71 ± 0.28; Mg 2+ , 3.70 ± 0.50; and Cl − , 50.15 ± 2.26. Water content was 0.76 ± 0.01 ml/g wet wt. Extracellular space was 0.37 ± 0.01 ml/g, and the vascular space 0.0238 ± 0.0002. The mean resting potential of the rabbit superior cervical ganglion was – 68.6 mv. After correction for extracellular electrolyte content, the potential differences, E Na , E K and E cl , were estimated to be +33.6 mv, –96.9 mv and ‐41.1 mv, respectively, in the ganglia. Permeability coefficients for K + , Na + , and Cl − were estimated to be 1:0.06:0.02. Replacement of sodium in physiological saline solution by lithium results in a displacement of 94 per cent of the sodium content of the ganglion and 69 per cent of the potassium after 30 min of equilibration.