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METABOLISM OF THE ETHANOLAMINE PHOSPHOGLYCERIDES OF MOUSE BRAIN MYELIN AND MICROSOMES 1
Author(s) -
Horrocks L. A.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb10338.x
Subject(s) - ethanolamine , microsome , biochemistry , metabolism , myelin , chemistry , biology , central nervous system , enzyme , endocrinology
— Three groups of six mice each were killed 1, 4 and 7 days after an intracerebral injection of [1,2‐ 14 C]ethanolamine. The specific radioactivities of the acid‐labile ethanolamine phosphoglycerides (ethanolamine plasmalogens) and of the acid‐stable ethanolamine phosphoglycerides (diacyl and alkyl acyl glycerophosphoryletholamines) from myelin and microsomal fractions were determined. All of these brain ethanolamine phosphoglycerides turn over rapidly with an apparent half‐life of less than 3 days. The biosynthesis of alkenyl acyl glycerophosphorylethanolamines from diacyl glycerophosphorylethanolamines in mouse brain myelin or microsomes is unlikely.