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BRAIN SEROTONIN CHANGES IN PHENYLALANINE‐FED RATS: SYNTHESIS STORAGE AND DEGRADATION 1
Author(s) -
Yuwiler A.,
Geller E.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb08990.x
Subject(s) - serotonin , monoamine oxidase , phenylalanine , reserpine , monoamine oxidase inhibitor , monoamine neurotransmitter , endocrinology , medicine , monoamine oxidase b , chemistry , biology , biochemistry , enzyme , amino acid , receptor
— The brain serotonin levels of rats maintained on a 5 % phenylalanine diet rose more slowly (0.18 μ g/g brain/hr) after administration of a monoamine oxidase inhibitor than did serotonin levels of controls (0.41 μ g/g brain/hr). The rate of brain serotonin decline following reserpine or dimethylaminobenzoyl methyl reserpate was the same for both groups as was basal monoamine oxidase activity. Brain uptake of monoamine oxidase inhibitor was also the same for both groups. It was concluded that the decrease in brain serotonin levels in phenylalanine‐fed animals was due to decreased serotonin formation rather than enhanced degradation. On the basis of available data it was concluded that both hydroxylase inhibition and inhibited precursor transport were involved.