Premium
GLUCOSE AND AMINO ACID METABOLISM IN SOME INVERTEBRATE NERVOUS SYSTEMS
Author(s) -
Bradford H. F.,
Chain E. B.,
Cory Helene T.,
Rose S. P. R.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb08987.x
Subject(s) - locust , glutamine , glutamate receptor , alanine , biology , biochemistry , metabolism , glycine , amino acid , snail , medicine , endocrinology , botany , receptor , ecology
— (1) The in vitro metabolism of [U‐ 14 C]glucose and [U‐ 14 C]glutamate was compared in snail, octopus and locust ganglia, and in rat cerebral cortex. (2) The metabolic patterns are quantitatively similar. The major labelled metabolites formed from glucose or glutamate by rat cortex and the invertebrate systems were CO 2 , aspartate, glutamate, glutamine and alanine. γ‐Aminobutyric acid (GABA) was formed in substantial amounts only by locust and rat. (3) A much larger proportion of labelled glucose and glutamate was converted to alanine by the invertebrates compared with rat cortex, although 14 CO 2 production was lower. (4) The effect of glucose in reducing aspartate formation and stimulating glutamine formation from [U‐ 14 C]glutamate in mammalian cortex was observed in the locust but not in the molluscs. (5) Labelled citric acid cycle intermediates were formed in substantial quantities from glucose and glutamate only by snail and locust.