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EFFECT OF HYPOTHYROIDISM ON IONIC METABOLISM AND Na‐K ACTIVATED ATP PHOSPHOHYDROLASE ACTIVITY IN THE DEVELOPING RAT BRAIN 1
Author(s) -
Valcana Theony,
Timiras Paola S.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb08983.x
Subject(s) - medicine , endocrinology , atpase , enzyme , chemistry , cerebellum , microsome , specific activity , enzyme assay , metabolism , cerebral cortex , biochemistry , biology
— The effects of neonatal hypothyroidism on electrolyte contents and the Na + and K + activated ATPase system was studied in the cerebral cortex and cerebellum of the developing rat. Neonatal hypothyroidism increased Na + and CI − contents and decreased K + and Mg 2+ contents in both brain areas. Hypothyroidism also resulted in a decrease in the specific activity of the Na‐K ATPase extracted by deoxycholate treatment from brain homogenate as well as in the specific activity of this enzyme in the heavy microsomal fraction. The decrease in Mg 2+ content and ATPase activity is discussed in relation to the changes occurring in Na + and K + . Both enzymic and ionic changes may underlie the biochemical and physiological abnormalities observed when the brain is deprived of thyroxine at critical stages of its development.