Premium
EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM 1
Author(s) -
Godin Y.,
Heiner L.,
Mark J.,
Mandel P.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb08975.x
Subject(s) - gaba transaminase , glutamate decarboxylase , anticonvulsant , glutamate receptor , metabolism , chemistry , transaminase , pharmacology , aminooxyacetic acid , drug , in vitro , biochemistry , enzyme , biology , neuroscience , epilepsy , receptor
— The effects on GABA metabolism of an anticonvulsant drug, di‐ n ‐propylacetate (DPA), were studied. Given intraperitoneally DPA increases the brain GABA content and does not change its biosynthesis from glutamic acid. However, it inhibits in vitro both glutamate decarboxylase and aminobutyrate transaminase (GABA‐T) activities. The inhibition is more pronounced on the GABA‐T and this observation might explain the increase of GABA level.