Premium
EFFECTS OF ANTIEPILEPTIC DRUGS ON BRAIN ENERGY RESERVES DURING CONVULSIONS 1
Author(s) -
King Lucy J.,
Carl Juanita
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb06863.x
Subject(s) - creatine , medicine , tonic (physiology) , chemistry , epilepsy , endocrinology , phenytoin , pharmacology , psychiatry
— Cerebral cortical ATP, P‐creatine, glucose, and lactate were measured 6 sec after 1 sec of 150/sec rectangular pulses, at 0,20 v, 40 v, 60 v, 80 v, or 100 v, applied to the heads of intact mice which had been given either no drug, phenobarbitone (25 mg/kg), trimethadione (600 mg/kg), or diphenylhydantoin (40 mg/kg), intraperitoneally. In general, regardless of stimulus strength or drug used, animals which exhibited maximal (tonic‐clonic) convulsions showed similar striking decreases in brain P‐creatine, decreases in ATP and glucose, and increases in lactate. On the other hand, in animals which exhibited less than maximal clinical response, there was little or no change in these metabolites. An exception was the case of diphenylhydantoin. Tonic‐clonic seizures did not occur after diphenylhydantoin administration, even with 100 v stimuli, but substrate changes at this voltage were, nevertheless, similar to those observed in brains of other mice undergoing maximal convulsions.