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MULTIPLE SUBSTRATE DETERMINATION OF MONOAMINE OXIDASE DISTRIBUTION AND IPRONIAZID INHIBITION IN RAT BRAIN 1
Author(s) -
Motte R. H.,
Schmidt D. E.,
Ruliffson W. S.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb06451.x
Subject(s) - iproniazid , monoamine oxidase , tryptamine , tyramine , serotonin , monoamine oxidase b , monoamine neurotransmitter , chemistry , biochemistry , dopamine , in vivo , enzyme , biology , endocrinology , receptor , microbiology and biotechnology
— —A variety of monoamine oxidase substrates (tyramine, dopamine, serotonin, tryptamine) have been used with and without Iproniazid inhibition to evaluate further the extent to which enzyme multiplicity may exist in various regions of rat brain. Levels of monoamine oxidase activity, as measured by ammonia production, were found to vary as a function of both brain area and kind of substrate used, in the absence as well as in the presence of Iproniazid, in vivo and in vitro. Similarity of substrate metabolizing patterns among the different brain areas, however, strongly suggests that only one kind of monoamine oxidase exists in rat brain.