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THE EFFECT OF ANTIOXIDANT‐DEFICIENCY ON PHOSPHOLIPID COMPOSITION IN THE CHICK BRAIN 1
Author(s) -
Witting L. A.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb05973.x
Subject(s) - encephalomalacia , phospholipid , antioxidant , endocrinology , medicine , composition (language) , arachidonic acid , chemistry , biochemistry , skeletal muscle , serine , biology , pathology , linguistics , philosophy , membrane , enzyme
— A significant increase in arachidonate was noted in the total phospholipids of brain of chicks with nutritional antioxidant‐deficiency and encephalomalacia. After thin‐layer chromatography of the brain lipids, this increase in arachidonate was found to be restricted to the phosphatidyl serine fraction. Significant decreases in docosahexaenoate and docosapentaenoate were noted in the phosphatidyl ethanolamine fraction. The changes in fatty acid composition of phospholipids in chick brain are comparable to those previously observed in phospholipids of skeletal muscle, liver and testes of the rat.