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CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE
Author(s) -
Kaita A. A.,
Goldberg A. M.
Publication year - 1969
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1969.tb05964.x
Subject(s) - acetylcholine , choline acetyltransferase , choline , chemistry , cholinergic , synaptic vesicle , biochemistry , in vitro , vesicle , endocrinology , biology , membrane
— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 m m and increases progressively to 45 per cent at a concentration of 100 m m . The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles.