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THE INTRASPINAL DISTRIBUTION OF SOME DEPRESSANT AMINO ACIDS
Author(s) -
Johnston G. A. R.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb11644.x
Subject(s) - taurine , strychnine , glycine , inhibitory postsynaptic potential , alanine , amino acid , cystathionine beta synthase , chemistry , serine , glycine receptor , depressant , pharmacology , neuroscience , biochemistry , biology , methionine , enzyme
— —Six known depressant amino acids were found in extracts of feline spinal grey matter: α‐alanine, cystathionine, GABA, glycine, serine and taurine. Of these, glycine has the distribution within the nervous system anticipated of a sub‐stance whose main function is as a spinal inhibitory transmitter at strychnine‐sensitive synapses, GABA being a likely transmitter candidate at any strychnine‐insensitive spinal inhibitory synapses. The intraspinal distributions of α‐alanine, cystathionine, serine and taurine reveal little to indicate that a synaptic role is a major function of these amino acids.