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PASSAGE OF 5‐HYDROXYTRYPTAMINE THROUGH THE BLOOD‐BRAIN BARRIER, ITS METABOLISM IN THE BRAIN AND ELIMINATION OF 5‐HYDROXYINDO‐LEACETIC ACID FROM THE BRAIN TISSUE
Author(s) -
Bulat M.,
Supek Z.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb11625.x
Subject(s) - blood–brain barrier , brain tissue , metabolism , incubation , mammalian brain , serotonin , penetration (warfare) , brain chemistry , chemistry , endocrinology , central nervous system , medicine , biology , biochemistry , neuroscience , receptor , operations research , engineering
— 5‐HT was injected intravenously in rats (10 mg/kg) and a marked increase in brain 5‐HT and 5‐HIAA was observed. For the first 10 min after injection the penetration of 5‐HT into the brain and formation of 5‐HIAA is evident. After 10 min degradation of exogenous 5‐HT and elimination of 5‐HIAA are prominent. Metabolism of exogenous 5‐HT in the brain is very fast (half‐life between 5 and 10 min; completely metabolized in approximately 80 min). The importance of these results in explaining the permeability of blood‐brain barrier to 5‐HT is discussed. Experiments on brain slices show that 5‐HT is more readily metabolized in brain tissue than eliminated into incubation medium. In contrast, 5‐HIAA very easily leaves brain tissue.