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LIQUID CATION EXCHANGE EXTRACTION OF CHOLINOMIMETIC ACTIVITY FROM BRAIN
Author(s) -
Johnston G. A. R.,
Lloyd Helen J.,
Stone Nancy
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb11622.x
Subject(s) - extraction (chemistry) , acetylcholine , chemistry , chromatography , biophysics , neuroscience , biochemistry , biology , pharmacology
— Liquid cation exchange extraction methods have been applied to the extraction of cholinomimetic activity from subcellular fractions, rich in nerve‐ending particles, derived from rat brain homogenates. The results obtained indicate that the activity is due largely to acetylcholine or closely related materials of similar basic strength, and that non‐basic materials, such as acetyl‐ l ‐carnitine, appear to contribute little to the observed activity.