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LOCALIZATION OF γ‐AMINOBUTYRIC‐α‐OXOGLUTARIC ACID TRANSAMINASE IN MOUSE BRAIN *
Author(s) -
Waksman A.,
Rubinstein M. K.,
Kuriyama K.,
Roberts E.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb11620.x
Subject(s) - aminobutyric acid , transaminase , biochemistry , enzyme , biology , brain tissue , chemistry , neuroscience , receptor
The distribution of γ‐aminobutyric‐α‐oxoglutarate transaminase (GABA‐T) has been studied in mouse brain by histochemical visualization on sections, quantitative determination in grossly dissected brain regions, and in subcellular fractions prepared from whole brain homogenates. The results indicate that GABA‐T is predominantly a mitochondrial enzyme and that its concentration is particularly high in brain stem areas. The results are discussed in relation to the overall function of the GABA system in the CNS.