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TRANSYNAPTIC STIMULATION OF PHOSPHATIDYLINOSITOL METABOLISM IN SYMPATHETIC NEURONS IN SITU
Author(s) -
LARRABEE M. G.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb10325.x
Subject(s) - stimulation , phosphatidylinositol , in situ , neuroscience , metabolism , sympathetic nervous system , chemistry , endocrinology , biology , medicine , microbiology and biotechnology , signal transduction , blood pressure , organic chemistry
— An increase in 32 P labelling of phosphatidylinositol, associated with synaptic activity, has previously been reported in excised sympathetic ganglia excited by preganglionic nerve impulses. In the present experiments a similar effect occurred in naturally‐stimulated ganglia. It occurred when the preganglionic impulses were either evoked by electrical stimulation of the preganglionic nerve or were discharged spontaneously from the central nervous system. Thus increased turnover of phosphatidylinositol appears to be a normal accompaniment of synaptic transmission in these ganglia.