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CEREBROSPINAL FLUID γ‐GLOBULINS IN SUBACUTE SCLEROSING LEUCOENCEPHALITIS
Author(s) -
Bergmann L.,
Dencker S. J.,
Johansson B. G.,
Svennerholm L.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb10322.x
Subject(s) - immunoelectrophoresis , size exclusion chromatography , gamma globulin , globulin , cerebrospinal fluid , antibody , homogeneous , alpha globulin , immunology , chemistry , biology , biochemistry , enzyme , gene , neuroscience , physics , thermodynamics
— Immunoelectrophoretis, gel filtration‐electrophoresis and immuno‐gel filtration of cerebral fluid samples obtained from five patients with subacute sclerosing leucoencephalitis and known to contain an abnormal γ‐globulin fraction (γe) produced strong evidence that the γ c ‐globulin is made up of several components of small molecular size. This fraction is obviously not homogeneous, since some of the cases show more than one precipitate on immuno‐gel filtration with immune serum against γ‐globulin. The γ c appears to be closely related to the Fab‐fragment of human γ‐globulin.