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ELEVATED PLASMA PHENYLALANINE CONCENTRATION AND LYSINE INCORPORATION INTO RIBOSOMAL PROTEIN OF DEVELOPING BRAIN
Author(s) -
Swaiman K. F.,
Hosfield W. B.,
Lemieux B.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb08968.x
Subject(s) - phenylalanine , hyperphenylalaninemia , lysine , endocrinology , medicine , chemistry , biochemistry , biology , amino acid
— Hyperphenylalaninemia was induced in 7‐day‐old rabbits over a 6‐hr period by intraperitoneal injection of phenylalanine. l ‐[U‐ 14 C]Lysine was injected intraperitoneally into these rabbits and into a control group. The rate of incorporation of l ‐[U‐ 14 C]lysme into brain ribosomal protein was decreased during a 5‐hr period in the presence of elevated plasma phenylalanine concentrations. Lysine transport from the peritoneum to the plasma was unaffected by the high plasma phenylalanine concentrations.