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SEIZURE THRESHOLD, ADRENALECTOMY AND SODIUM‐POTASSIUM STIMULATED ATPase IN RAT BRAIN * 1
Author(s) -
Gallagher B. B.,
Glaser G. H.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb08950.x
Subject(s) - adrenalectomy , convulsant , medicine , endocrinology , potassium , sodium , chemistry , kidney , seizure threshold , enzyme assay , enzyme , atpase , biology , biochemistry , epilepsy , neuroscience , anticonvulsant , receptor , organic chemistry
— Adrenalectomy in the rat was shown to lower seizure threshold measured with the volatile convulsant hexafluorodiethyl ether. Although the expected hyponatraemia and hyperkalaemia were demonstrated in the adrenalectomized rats, there was no associated alteration in Na‐K stimulated Mg‐ATPase activity either in the whole rat brain or in a microsomal fraction. These results in brain tissue are contrasted with the marked decrease in this enzyme that occurs in kidney tissue of the rat following adrenalectomy. It was suggested that the activity of the enzyme system responsible for active cation transport responds directly in proportion to the work of active transport required by the individual tissue.