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SODIUM STIMULATED [ 14 C]ADENOSINE DIPHOSPHATE‐ADENOSINE TRIPHOSPHATE EXCHANGE ACTIVITY IN BRAIN MICROSOMES
Author(s) -
Stahl W. L.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb08948.x
Subject(s) - ouabain , oligomycin , adenosine triphosphate , microsome , chemistry , sodium , atpase , adenosine diphosphate , adenosine , nucleotide , biochemistry , enzyme , biology , platelet , platelet aggregation , organic chemistry , gene , immunology
— An ADP‐ATP exchange reaction was studied in NaI‐treated microsomes from rat brain. At low concentrations of MgCl 2 a nucleotide exchange reaction, elicited in the presence of Na + , had an absolute specificity for ATP. The reaction was stimulated by oligomycin and inhibited by ouabain and EDTA. It is probable that this Na + ‐stimulated ADP‐ATP exchange reaction is a component of the Na‐K ATPase system.