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THE EFFECTS OF 4‐HYDROXYBUTYRIC ACID ON THE BIOSYNTHESIS OF AMINO ACIDS IN THE CENTRAL NERVOUS SYSTEM
Author(s) -
Godin Y.,
Mark J.,
Mandel P.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb06826.x
Subject(s) - glutamine , metabolism , carbohydrate metabolism , glutamic acid , chemistry , central nervous system , aspartic acid , amino acid , biochemistry , glutamate receptor , biology , endocrinology , receptor
—The effect of 4‐hydroxybutyrate (GHB) on cerebral glucose metabolism has been studied. GHB increases the glucose level, decreases the lactate concentration and diminishes the incorporation of glucose carbon into glutamic acid, glutamine, aspartic acid and GABA in the brain of the rat in a state of general anaesthesia. The data reported here suggest that GHB interferes in the metabolism of glucose in brain.