Premium
THE FIXATION OF TETANUS TOXIN BY SYNAPTIC MEMBRANES
Author(s) -
Mellanby Jane,
Whittaker V. P.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb06197.x
Subject(s) - synaptosome , toxin , synaptic vesicle , membrane , tetanus , ganglioside , vesicle , biochemistry , chemistry , biophysics , biology , immunology , vaccination
—The ability of subfractions of disrupted synaptosomes to bind tetanus toxin has been studied. Synaptic vesicles had little toxin‐fixing capacity, but a fraction believed on morphological appearance and enzymic composition to be rich in external synaptosome membranes had a toxin‐fixing capacity about 10 times that of the synaptic vesicles and over twice that of the initial brain homogenate. Mitochondria also had a low toxin‐fixing capacity and other membrane fractions had an intermediate value. The results are discussed in relation to the known role of ganglioside in fixing toxin.