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COMPARATIVE STUDIES ON THE OXIDATION OF 5‐HYDROXYTRYPTAMINE AND 3,4‐DIMETHOXY‐ PHENYLETHYLAMINE IN RAT, DOG AND HUMAN BRAIN
Author(s) -
Huszti Z.,
Borsy J.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb05922.x
Subject(s) - monoamine oxidase , enzyme , chemistry , serotonin , biochemistry , monoamine neurotransmitter , substrate (aquarium) , monoamine oxidase b , monoamine oxidase a , dopamine , stereochemistry , biology , endocrinology , ecology , receptor
— Comparative studies were carried out on 5‐hydroxytryptamine (5‐HT) and 3,4‐dimethoxyphenylethylamine (DMPEA) oxidation using brain homogenates from different animals as the source of enzyme. Differences in the enzyme saturation curves, in the inhibitor spectra and variations of enzyme activity depending on the substrate used, suggested that the enzymes taking part in the oxidation of 5‐HT and of DMPEA slightly differ from each other. Differences were interpreted on the basis of the heterogeneity of monoamine oxidase (MAO), suggested by earlier investigations. Thus the possibility of an individual inhibition of the degradation of certain amines has to be considered.