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THE EFFECT OF BILIRUBIN ON THE ENERGY METABOLISM OF BRAIN MITOCHONDRIA
Author(s) -
Vogt Molly T.,
Basford R. E.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb05909.x
Subject(s) - bilirubin , oxidative phosphorylation , weanling , mitochondrion , atpase , albumin , endogeny , metabolism , biochemistry , medicine , endocrinology , chemistry , inhibitory postsynaptic potential , serum albumin , biology , enzyme
— Unconjugated bilirubin caused uncoupling of oxidative phosphorylation in brain mitochondria prepared from mature or weanling rats. Human serum albumin in an amount sufficient to bind 100 per cent of the added bilirubin was able to protect the mitochondria from the inhibitory effects of bilirubin. Bilirubin inhibited both the endogenous and DNP‐activated ATPase activities but had no effect upon the Mg 2+ ‐stimulated ATPase; albumin prevented the inhibition.