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CONTROL OF GLYCOGEN LEVELS IN BRAIN 1
Author(s) -
Nelson S. R.,
Schulz D. W.,
Passonneau Janet V.,
Lowry O. H.
Publication year - 1968
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1968.tb05904.x
Subject(s) - glycogen , endocrinology , medicine , phenobarbital , glycogen synthase , plasma glucose , diabetes mellitus , insulin , chemistry , alloxan , carbohydrate metabolism , biology
— Prolonged (6 hr) anaesthesia with phenobarbital in mice or rats results in a doubling or tripling of brain glycogen. Increases were also observed if high levels of plasma glucose were maintained for 6 hr. In alloxan diabetes brain glycogen was not elevated in spite of the high plasma glucose concentrations. However, administration of insulin to such diabetic animals, together with enough glucose to maintain high plasma levels, resulted in at least a doubling of brain glycogen in 6 hr. Phenobarbital can still increase brain glycogen in diabetic animals. In all of the conditions associated with increased glycogen deposition, increases were found in the ratio of brain glucose to plasma glucose. Cerebral glucose‐6‐P levels were also increased whereas there were no substantial changes in levels of UDP‐glucose or glucose‐1,6‐diphosphate.