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LIPID BIOSYNTHESIS IN ANOXIC‐ISCHAEMIC RAT BRAIN *
Author(s) -
Kosow David P.,
Schwarz Henry P.,
Marmolejo Alfonso
Publication year - 1966
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1966.tb04270.x
Subject(s) - anoxic waters , chemistry , ischaemic stroke , biology , biochemistry , endocrinology , medicine , ischemia , environmental chemistry
The uptake of [U‐ 14 C]glucose and [2‐ 14 C]acetate into lipids was measured in brain slices from anoxic, unilaterally ischaemic, unilaterally anoxic‐ischaemic, and control rats. The rate of incorporation was significantly decreased in the brain slices from the treated animals except for the contralateral hemisphere of the unilaterally ischaemic animals. Also, there was no significant difference between the anoxic and the anoxic‐ischaemic cerebral hemispheres of the anoxic‐ischaemic animals. Fractionation of the total lipid extract demonstrated that the decrease in incorporation was general and not due to any particular class of lipid.