Premium
STRUCTURAL STUDIES ON SULPHATIDES IN METACHROMATIC LEUCODYSTROPHY
Author(s) -
Malone Michael J.,
Stoffyn Pierre,
Moser Hugo
Publication year - 1966
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1966.tb04262.x
Subject(s) - metachromasia , galactose , chemistry , hexose , biochemistry , biology , genetics , enzyme , staining
SUMMARY Sulphatides have been isolated by a newly developed method from the brain white matter of normal human adult and child, and of two patients with metachromatic leucodystrophy. Only galactose was found in chromatographic analysis of the carbohydrate component. Following permethylation of the sulphatides, the methylated hexose, in all cases, was 2,4,6‐trimethylgalactose. The sulphate group is located solely at the C‐3 position of the galactopyranose moiety, and in metachromatic leucodystrophy, although there is an accumulation of sulphatides, their composition and structure remain normal.