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PROVOCATION OF CEREBRAL SEIZURES BY DERANGEMENT OF THE NATURAL BALANCE BETWEEN GLUTAMIC ACID AND γ‐AMINOBUTYRIC ACID
Author(s) -
Wiechert P.,
Herbst A.
Publication year - 1966
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1966.tb03332.x
Subject(s) - provocation test , epilepsy , aminobutyric acid , glutamic acid , anesthesia , medicine , chemistry , biochemistry , amino acid , pathology , receptor , alternative medicine , psychiatry
SUMMARY After intracisternal injection of glutamic acid and pyridoxal 5‐phosphate, cerebral seizures could be evoked in dogs. With a small dose, these seizures were limited predominantly to the facial area. An interruption or prevention of the seizures was possible by intracistemal injection of γ‐aininobutyric acid or by pretreatment of the animals with α‐methyl‐α‐ethyl‐succinimide. The correspondence of clinical symptoms and therapeutic effect suggests a relation between these experimentally‐induced seizures and temporal lobe epilepsy in man.