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A HISTOCHEMICAL STUDY OF DPN‐DIAPHORASE IN HUMAN WHITE MATTER WITH SOME NOTES ON MYELINATION
Author(s) -
Friede Reinhard L.
Publication year - 1961
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1961.tb13522.x
Subject(s) - neuropathology , citation , library science , white (mutation) , white paper , white matter , psychology , medicine , computer science , history , pathology , biology , magnetic resonance imaging , gene , biochemistry , disease , archaeology , radiology
THERE is some indication of differences in the anatomical and chemical organization of individual fibre tracts in the brain, such as the outstanding activity of alkaline phosphatase in the retroflex bundle of the guinea pig (SHIMIZU, 1950) and the different rates of synthesis of acetylcholine in various fibre tracts (FELDBERG and VOGT, 1948). This paper reports on the distribution of DPN-diaphorase in human white matter. The distribution of enzyme activity in human grey matter will not be touched upon. It resembles, in principle, that of succinic dehydrogenase in the guinea pig brain which, in turn, is similar to that of several oxidative enzymes in cat brain as documented recently in an histochemical atlas (FRIEDE, 1961). The activity of oxidative enzymes is much less in white matter than in grey matter, as shown by both biochemical and histochemical data. Histochemical studies revealed detailed differences in the cytological enzyme distribution in the various tracts. Some data on myelination and on certain features of enzyme transport in axons were included in this study because they imply a difference in the chemical organization of the tracts.