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THE QUANTITATIVE HISTOCHEMISTRY OF THE CEREBRAL CORTEX—III. ANALYSES AT 50 μ INTERVALS COMPARED WITH ANALYSES BY ARCHITECTONIC LAYERS IN THE MOTOR AND VISUAL CORTICES *
Author(s) -
Robins Eli,
Smith David E.,
Eydt Kathryn M.
Publication year - 1956
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1956.tb12056.x
Subject(s) - neurology , medicine , psychology , psychiatry
THE measurements of chemical constituents and enzymes in the motor and visual cortices of the monkey reported in the first two papers of this series (ROBINS, MITH, and EYDT, 1956: ROBINS, SMITH, EYDT, and MCCAMAN, 1956) were made at nine architectonic levels of the cortex and in the immediately subjacent white matter. In the motor cortex, which is approximately 4 mm thick from pial surface to subjacent white matter, this means that each measurement averaged approximately 400 p apart. In the visual cortex. which is approximately 2 mm in thickness, this means that each measurement averaged approximately 200 p apart. Whether changes in the amounts of any of these constituents occurred between the loci measured was a n important question. It was decided to measure protein, fumarase, and glutamic dehydrogenase at 50 ,u intervals throughout the depth of the cortex. Protein was chosen as a n example of a chemical constituent, fumarase as a n enzyme with a distribution in both cortices similar to the majority of the other enzymes studied, and glutamic dehydrogenase as an enzyme with an atypical distribution. Also, it was of interest to confirm the previously found increase in glutamic dehydrogenase activity in the deeper layers of both cortices.