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ABO and RhD blood groups and gestational hypertensive disorders: a population‐based cohort study
Author(s) -
Lee BK,
Zhang Z,
Wikman A,
Lindqvist PG,
Reilly M
Publication year - 2012
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2012.03421.x
Subject(s) - medicine , eclampsia , abo blood group system , obstetrics , odds ratio , preeclampsia , gestational hypertension , population , cohort , pregnancy , cohort study , gestational age , gynecology , genetics , environmental health , biology
Please cite this paper as: Lee B, Zhang Z, Wikman A, Lindqvist P, Reilly M. ABO and RhD blood groups and gestational hypertensive disorders: a population‐based cohort study. BJOG 2012;119:1232–1237. Objective To examine the association between ABO and RhD blood groups and gestational hypertensive disorders in a large population‐based cohort. Design Cohort study. Risks of gestational hypertensive disorders, pre‐eclampsia, and severe pre‐eclampsia, estimated by odds ratios for maternal ABO blood group and RhD status. Setting National health registers of Sweden. Population All singleton deliveries in Sweden born to first‐time mothers during the period 1987–2002 [total n = 641 926; any gestational hypertensive disorders, n = 39 011 (6.1%); pre‐eclampsia cases, n = 29 337 (4.6%); severe pre‐eclampsia cases, n = 8477 (1.3%)]. Methods Using blood group O as a reference, odds ratios of gestational hypertensive disorders, pre‐eclampsia, and severe pre‐eclampsia were obtained from logistic regression models adjusted for potential confounding factors. Main outcome measures Gestational hypertensive disorders, pre‐eclampsia, and severe pre‐eclampsia. Results Compared with blood group O, all non‐O blood groups had modest but statistically significantly higher odds of pre‐eclampsia. Blood group AB had the highest risk for pre‐eclampsia (OR = 1.10, 95% CI 1.04–1.16) and severe pre‐eclampsia (OR = 1.18, 95% CI 1.07–1.30). RhD‐positive mothers had a small increased risk for pre‐eclampsia (OR = 1.07, 95% CI 1.03–1.10). Conclusions In the largest study on this topic to date, women with AB blood group have the highest risks of gestational hypertensive disorders, pre‐eclampsia, and severe pre‐eclampsia, whereas women with O blood group have the lowest risks of developing these disorders. Although the magnitude of increased risk is small, this finding may help improve our understanding of the etiology of pre‐eclampsia.