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Association of the interferon‐γ gene (CA) n repeat polymorphism with endometriosis
Author(s) -
Kim JJ,
Choi YM,
Hwang SS,
Yoon SH,
Lee GH,
Chae SJ,
Hwang KR,
Moon SY
Publication year - 2011
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2011.02963.x
Subject(s) - genotype , allele , endometriosis , genotyping , allele frequency , biology , population , genetics , polymerase chain reaction , microsatellite , gene polymorphism , gene , microbiology and biotechnology , medicine , environmental health
Please cite this paper as: Kim J, Choi Y, Hwang S, Yoon S, Lee G, Chae S, Hwang K, Moon S. Association of the interferon‐γ gene (CA) n repeat polymorphism with endometriosis. BJOG 2011;118:1061–1066. Objective To investigate whether the interferon‐γ ( IFN‐γ ) gene (CA) n repeat polymorphism is associated with susceptibility to endometriosis. Design Case–control study. Setting University Department of Obstetrics and Gynaecology. Population Women with ( n = 622) and without ( n = 442) endometriosis. Methods Genotyping was performed by fluorescent polymerase chain reaction (PCR) and gene‐scan analysis. Main outcome measures Genotype distribution and allele frequency of the dinucleotide (CA) n repeat polymorphism in the IFN‐γ gene. Results Seven alleles (12–18 repeats) of the IFN‐γ gene (CA) n repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12–13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001). Conclusions Our results suggest that the (CA) n repeat polymorphism in the IFN‐γ gene may be associated with a risk of endometriosis in the South Korean population.